| Family1 | Species1 | Family2 | Species2 | SCUS score | Similarity |
| Malvaceae | Gossypium hirsutum | Malvaceae | Gossypium raimondii | 9.92 | Highly Similar |
| Malvaceae | Gossypium hirsutum | Chenopodiaceae | Spinacia oleracea | 9.74 | Highly Similar |
| Malvaceae | Gossypium hirsutum | Solanaceae | Solanum melongena | 9.70 | Highly Similar |
| Malvaceae | Gossypium hirsutum | Chenopodiaceae | Beta vulgaris subsp. vulgaris | 9.58 | Highly Similar |
| Malvaceae | Gossypium hirsutum | Apiaceae | Daucus carota subsp. sativus | 9.51 | Highly Similar |
| Malvaceae | Gossypium hirsutum | Cucurbitaceae | Benincasa hispida | 9.46 | Highly Similar |
| Malvaceae | Gossypium hirsutum | Chenopodiaceae | Chenopodium quinoa | 9.40 | Highly Similar |
| Malvaceae | Gossypium hirsutum | Cucurbitaceae | Cucumis sativus | 9.33 | Highly Similar |
| Malvaceae | Gossypium hirsutum | Solanaceae | Capsicum annuum | 9.25 | Highly Similar |
| Malvaceae | Gossypium hirsutum | Solanaceae | Solanum lycopersicum | 9.24 | Highly Similar |
| Malvaceae | Gossypium hirsutum | Cucurbitaceae | Cucumis melo | 9.22 | Highly Similar |
| Malvaceae | Gossypium hirsutum | Solanaceae | Solanum pennellii | 9.22 | Highly Similar |
| Malvaceae | Gossypium hirsutum | Solanaceae | Nicotiana tomentosiformis | 9.11 | Highly Similar |
| Malvaceae | Gossypium hirsutum | Solanaceae | Solanum tuberosum | 9.11 | Highly Similar |
| Malvaceae | Gossypium hirsutum | Solanaceae | Nicotiana sylvestris | 9.09 | Highly Similar |
| Malvaceae | Gossypium hirsutum | Solanaceae | Nicotiana tabacum | 9.06 | Highly Similar |
| Malvaceae | Gossypium hirsutum | Fabaceae | Cicer arietinum | 9.03 | Highly Similar |
| Malvaceae | Gossypium hirsutum | Fabaceae | Medicago truncatula | 9.03 | Highly Similar |
| Malvaceae | Gossypium hirsutum | Solanaceae | Nicotiana attenuata | 9.03 | Highly Similar |
| Malvaceae | Gossypium hirsutum | Cucurbitaceae | Momordica charantia | 8.96 | Similar |