| Family1 | Species1 | Family2 | Species2 | SCUS score | Similarity |
| Euphorbiaceae | Manihot esculenta | Solanaceae | Nicotiana tabacum | 8.73 | Similar |
| Euphorbiaceae | Manihot esculenta | Solanaceae | Nicotiana tomentosiformis | 8.68 | Similar |
| Euphorbiaceae | Manihot esculenta | Poaceae | Oryza brachyantha | 4.33 | Dis similar |
| Euphorbiaceae | Manihot esculenta | Poaceae | Oryza sativa Japonica Group | 4.25 | Dis similar |
| Euphorbiaceae | Manihot esculenta | Poaceae | Panicum hallii | 4.16 | Dis similar |
| Euphorbiaceae | Manihot esculenta | Poaceae | Panicum virgatum | 4.41 | Dis similar |
| Euphorbiaceae | Manihot esculenta | Fabaceae | Phaseolus vulgaris | 9.43 | Highly Similar |
| Euphorbiaceae | Manihot esculenta | Fabaceae | Prosopis alba | 8.77 | Similar |
| Euphorbiaceae | Manihot esculenta | Brassicaceae | Raphanus sativus | 3.48 | Dis similar |
| Euphorbiaceae | Manihot esculenta | Euphorbiaceae | Ricinus communis | 9.67 | Highly Similar |
| Euphorbiaceae | Manihot esculenta | Poaceae | Saccharum officinarum | 5.41 | Moderately similar |
| Euphorbiaceae | Manihot esculenta | Pedaliaceae | Sesamum indicum | 8.29 | Similar |
| Euphorbiaceae | Manihot esculenta | Poaceae | Setaria italica | 4.28 | Dis similar |
| Euphorbiaceae | Manihot esculenta | Poaceae | Setaria viridis | 4.21 | Dis similar |
| Euphorbiaceae | Manihot esculenta | Solanaceae | Solanum lycopersicum | 8.09 | Similar |
| Euphorbiaceae | Manihot esculenta | Solanaceae | Solanum melongena | 8.11 | Similar |
| Euphorbiaceae | Manihot esculenta | Solanaceae | Solanum pennellii | 8.06 | Similar |
| Euphorbiaceae | Manihot esculenta | Solanaceae | Solanum tuberosum | 8.36 | Similar |
| Euphorbiaceae | Manihot esculenta | Poaceae | Sorghum bicolor | 4.46 | Dis similar |
| Euphorbiaceae | Manihot esculenta | Chenopodiaceae | Spinacia oleracea | 8.03 | Similar |