| Family1 | Species1 | Family2 | Species2 | SCUS score | Similarity |
| Solanaceae | Nicotiana sylvestris | Solanaceae | Solanum melongena | 9.37 | Highly Similar |
| Solanaceae | Nicotiana sylvestris | Solanaceae | Solanum pennellii | 9.35 | Highly Similar |
| Solanaceae | Nicotiana sylvestris | Solanaceae | Solanum tuberosum | 9.62 | Highly Similar |
| Solanaceae | Nicotiana sylvestris | Poaceae | Sorghum bicolor | 4.54 | Dis similar |
| Solanaceae | Nicotiana sylvestris | Chenopodiaceae | Spinacia oleracea | 9.29 | Highly Similar |
| Solanaceae | Nicotiana sylvestris | Asteraceae | Tagetes erecta | 3.08 | Dis similar |
| Solanaceae | Nicotiana sylvestris | Malvaceae | Theobroma cacao | 9.03 | Highly Similar |
| Solanaceae | Nicotiana sylvestris | Poaceae | Triticum aestivum | 4.36 | Dis similar |
| Solanaceae | Nicotiana sylvestris | Poaceae | Triticum dicoccoides | 4.23 | Dis similar |
| Solanaceae | Nicotiana sylvestris | Fabaceae | Vigna angularis | 9.07 | Highly Similar |
| Solanaceae | Nicotiana sylvestris | Fabaceae | Vigna radiata var. radiata | 9.13 | Highly Similar |
| Solanaceae | Nicotiana sylvestris | Fabaceae | Vigna unguiculata | 9.10 | Highly Similar |
| Solanaceae | Nicotiana sylvestris | Poaceae | Zea mays | 4.58 | Dis similar |
| Solanaceae | Nicotiana tabacum | Fabaceae | Abrus precatorius | 8.88 | Similar |
| Solanaceae | Nicotiana tabacum | Poaceae | Aegilops tauschii subsp. strangulata | 4.13 | Dis similar |
| Solanaceae | Nicotiana tabacum | Brassicaceae | Arabidopsis lyrata subsp. lyrata | 5.05 | Moderately similar |
| Solanaceae | Nicotiana tabacum | Brassicaceae | Arabidopsis thaliana | 4.90 | Dis similar |
| Solanaceae | Nicotiana tabacum | Fabaceae | Arachis duranensis | 9.13 | Highly Similar |
| Solanaceae | Nicotiana tabacum | Fabaceae | Arachis hypogaea | 9.13 | Highly Similar |
| Solanaceae | Nicotiana tabacum | Fabaceae | Arachis ipaensis | 9.13 | Highly Similar |