| Family1 | Species1 | Family2 | Species2 | SCUS score | Similarity |
| Solanaceae | Nicotiana tabacum | Asteraceae | Cynara cardunculus var. scolymus | 6.59 | Moderately similar |
| Solanaceae | Nicotiana tabacum | Apiaceae | Daucus carota subsp. sativus | 9.46 | Highly Similar |
| Solanaceae | Nicotiana tabacum | Malvaceae | Durio zibethinus | 9.08 | Highly Similar |
| Solanaceae | Nicotiana tabacum | Brassicaceae | Eutrema salsugineum | 4.60 | Dis similar |
| Solanaceae | Nicotiana tabacum | Fabaceae | Glycine max | 8.56 | Similar |
| Solanaceae | Nicotiana tabacum | Fabaceae | Glycine soja | 8.58 | Similar |
| Solanaceae | Nicotiana tabacum | Malvaceae | Gossypium arboreum | 9.06 | Highly Similar |
| Solanaceae | Nicotiana tabacum | Malvaceae | Gossypium hirsutum | 9.06 | Highly Similar |
| Solanaceae | Nicotiana tabacum | Malvaceae | Gossypium raimondii | 8.99 | Similar |
| Solanaceae | Nicotiana tabacum | Asteraceae | Helianthus annuus | 5.40 | Moderately similar |
| Solanaceae | Nicotiana tabacum | Malvaceae | Herrania umbratica | 8.99 | Similar |
| Solanaceae | Nicotiana tabacum | Euphorbiaceae | Hevea brasiliensis | 8.35 | Similar |
| Solanaceae | Nicotiana tabacum | Poaceae | Hordeum vulgare | 4.62 | Dis similar |
| Solanaceae | Nicotiana tabacum | Euphorbiaceae | Jatropha curcas | 9.28 | Highly Similar |
| Solanaceae | Nicotiana tabacum | Asteraceae | Lactuca sativa | 7.22 | Similar |
| Solanaceae | Nicotiana tabacum | Fabaceae | Lupinus angustifolius | 9.30 | Highly Similar |
| Solanaceae | Nicotiana tabacum | Euphorbiaceae | Manihot esculenta | 8.73 | Similar |
| Solanaceae | Nicotiana tabacum | Fabaceae | Medicago truncatula | 9.05 | Highly Similar |
| Solanaceae | Nicotiana tabacum | Cucurbitaceae | Momordica charantia | 8.18 | Similar |
| Solanaceae | Nicotiana tabacum | Musaceae | Musa acuminata subsp. malaccensis | 6.31 | Moderately similar |