| Family1 | Species1 | Family2 | Species2 | SCUS score | Similarity |
| Poaceae | Setaria italica | Brassicaceae | Arabidopsis thaliana | 3.37 | Dis similar |
| Poaceae | Setaria italica | Fabaceae | Arachis duranensis | 5.05 | Moderately similar |
| Poaceae | Setaria italica | Fabaceae | Arachis hypogaea | 5.05 | Moderately similar |
| Poaceae | Setaria italica | Fabaceae | Arachis ipaensis | 5.04 | Moderately similar |
| Poaceae | Setaria italica | Cucurbitaceae | Benincasa hispida | 4.96 | Dis similar |
| Poaceae | Setaria italica | Chenopodiaceae | Beta vulgaris subsp. vulgaris | 4.38 | Dis similar |
| Poaceae | Setaria italica | Poaceae | Brachypodium distachyon | 9.59 | Highly Similar |
| Poaceae | Setaria italica | Brassicaceae | Brassica juncea | 4.01 | Dis similar |
| Poaceae | Setaria italica | Brassicaceae | Brassica napus | 4.05 | Dis similar |
| Poaceae | Setaria italica | Brassicaceae | Brassica oleracea var. oleracea | 4.04 | Dis similar |
| Poaceae | Setaria italica | Brassicaceae | Brassica rapa | 4.01 | Dis similar |
| Poaceae | Setaria italica | Fabaceae | Cajanus cajan | 4.98 | Dis similar |
| Poaceae | Setaria italica | Brassicaceae | Camelina sativa | 3.60 | Dis similar |
| Poaceae | Setaria italica | Brassicaceae | Capsella rubella | 3.76 | Dis similar |
| Poaceae | Setaria italica | Solanaceae | Capsicum annuum | 4.23 | Dis similar |
| Poaceae | Setaria italica | Chenopodiaceae | Chenopodium quinoa | 4.34 | Dis similar |
| Poaceae | Setaria italica | Fabaceae | Cicer arietinum | 3.82 | Dis similar |
| Poaceae | Setaria italica | Rutaceae | Citrus clementina | 4.86 | Dis similar |
| Poaceae | Setaria italica | Rutaceae | Citrus sinensis | 4.84 | Dis similar |
| Poaceae | Setaria italica | Cucurbitaceae | Cucumis melo | 4.70 | Dis similar |