| Family1 | Species1 | Family2 | Species2 | SCUS score | Similarity |
| Chenopodiaceae | Spinacia oleracea | Fabaceae | Medicago truncatula | 9.26 | Highly Similar |
| Chenopodiaceae | Spinacia oleracea | Cucurbitaceae | Momordica charantia | 8.70 | Similar |
| Chenopodiaceae | Spinacia oleracea | Musaceae | Musa acuminata subsp. malaccensis | 6.57 | Moderately similar |
| Chenopodiaceae | Spinacia oleracea | Solanaceae | Nicotiana attenuata | 9.22 | Highly Similar |
| Chenopodiaceae | Spinacia oleracea | Solanaceae | Nicotiana sylvestris | 9.29 | Highly Similar |
| Chenopodiaceae | Spinacia oleracea | Solanaceae | Nicotiana tabacum | 9.26 | Highly Similar |
| Chenopodiaceae | Spinacia oleracea | Solanaceae | Nicotiana tomentosiformis | 9.31 | Highly Similar |
| Chenopodiaceae | Spinacia oleracea | Poaceae | Oryza brachyantha | 4.74 | Dis similar |
| Chenopodiaceae | Spinacia oleracea | Poaceae | Oryza sativa Japonica Group | 4.77 | Dis similar |
| Chenopodiaceae | Spinacia oleracea | Poaceae | Panicum hallii | 4.40 | Dis similar |
| Chenopodiaceae | Spinacia oleracea | Poaceae | Panicum virgatum | 4.58 | Dis similar |
| Chenopodiaceae | Spinacia oleracea | Fabaceae | Phaseolus vulgaris | 8.25 | Similar |
| Chenopodiaceae | Spinacia oleracea | Fabaceae | Prosopis alba | 8.83 | Similar |
| Chenopodiaceae | Spinacia oleracea | Brassicaceae | Raphanus sativus | 5.38 | Moderately similar |
| Chenopodiaceae | Spinacia oleracea | Euphorbiaceae | Ricinus communis | 8.28 | Similar |
| Chenopodiaceae | Spinacia oleracea | Poaceae | Saccharum officinarum | 7.16 | Similar |
| Chenopodiaceae | Spinacia oleracea | Pedaliaceae | Sesamum indicum | 8.57 | Similar |
| Chenopodiaceae | Spinacia oleracea | Poaceae | Setaria italica | 4.55 | Dis similar |
| Chenopodiaceae | Spinacia oleracea | Poaceae | Setaria viridis | 4.50 | Dis similar |
| Chenopodiaceae | Spinacia oleracea | Solanaceae | Solanum lycopersicum | 9.50 | Highly Similar |