| Family1 | Species1 | Family2 | Species2 | SCUS score | Similarity |
| Cucurbitaceae | Cucumis melo | Cucurbitaceae | Cucurbita pepo subsp. pepo | 8.95 | Similar |
| Cucurbitaceae | Cucumis melo | Asteraceae | Cynara cardunculus var. scolymus | 8.28 | Similar |
| Cucurbitaceae | Cucumis melo | Apiaceae | Daucus carota subsp. sativus | 8.73 | Similar |
| Cucurbitaceae | Cucumis melo | Malvaceae | Durio zibethinus | 7.47 | Similar |
| Cucurbitaceae | Cucumis melo | Brassicaceae | Eutrema salsugineum | 6.29 | Moderately similar |
| Cucurbitaceae | Cucumis melo | Fabaceae | Glycine max | 7.13 | Similar |
| Cucurbitaceae | Cucumis melo | Fabaceae | Glycine soja | 7.16 | Similar |
| Cucurbitaceae | Cucumis melo | Malvaceae | Gossypium arboreum | 9.22 | Highly Similar |
| Cucurbitaceae | Cucumis melo | Malvaceae | Gossypium hirsutum | 9.22 | Highly Similar |
| Cucurbitaceae | Cucumis melo | Malvaceae | Gossypium raimondii | 9.30 | Highly Similar |
| Cucurbitaceae | Cucumis melo | Asteraceae | Helianthus annuus | 7.07 | Similar |
| Cucurbitaceae | Cucumis melo | Malvaceae | Herrania umbratica | 7.51 | Similar |
| Cucurbitaceae | Cucumis melo | Euphorbiaceae | Hevea brasiliensis | 6.73 | Moderately similar |
| Cucurbitaceae | Cucumis melo | Poaceae | Hordeum vulgare | 4.89 | Dis similar |
| Cucurbitaceae | Cucumis melo | Euphorbiaceae | Jatropha curcas | 7.59 | Similar |
| Cucurbitaceae | Cucumis melo | Asteraceae | Lactuca sativa | 8.78 | Similar |
| Cucurbitaceae | Cucumis melo | Fabaceae | Lupinus angustifolius | 7.62 | Similar |
| Cucurbitaceae | Cucumis melo | Euphorbiaceae | Manihot esculenta | 7.11 | Similar |
| Cucurbitaceae | Cucumis melo | Fabaceae | Medicago truncatula | 8.68 | Similar |
| Cucurbitaceae | Cucumis melo | Cucurbitaceae | Momordica charantia | 8.93 | Similar |