| Family1 | Species1 | Family2 | Species2 | SCUS score | Similarity |
| Cucurbitaceae | Cucumis sativus | Solanaceae | Nicotiana tabacum | 8.43 | Similar |
| Cucurbitaceae | Cucumis sativus | Solanaceae | Nicotiana tomentosiformis | 8.48 | Similar |
| Cucurbitaceae | Cucumis sativus | Poaceae | Oryza brachyantha | 4.92 | Dis similar |
| Cucurbitaceae | Cucumis sativus | Poaceae | Oryza sativa Japonica Group | 5.00 | Moderately similar |
| Cucurbitaceae | Cucumis sativus | Poaceae | Panicum hallii | 4.52 | Dis similar |
| Cucurbitaceae | Cucumis sativus | Poaceae | Panicum virgatum | 4.67 | Dis similar |
| Cucurbitaceae | Cucumis sativus | Fabaceae | Phaseolus vulgaris | 7.51 | Similar |
| Cucurbitaceae | Cucumis sativus | Fabaceae | Prosopis alba | 8.19 | Similar |
| Cucurbitaceae | Cucumis sativus | Brassicaceae | Raphanus sativus | 6.20 | Moderately similar |
| Cucurbitaceae | Cucumis sativus | Euphorbiaceae | Ricinus communis | 7.46 | Similar |
| Cucurbitaceae | Cucumis sativus | Poaceae | Saccharum officinarum | 7.92 | Similar |
| Cucurbitaceae | Cucumis sativus | Pedaliaceae | Sesamum indicum | 8.15 | Similar |
| Cucurbitaceae | Cucumis sativus | Poaceae | Setaria italica | 4.67 | Dis similar |
| Cucurbitaceae | Cucumis sativus | Poaceae | Setaria viridis | 4.63 | Dis similar |
| Cucurbitaceae | Cucumis sativus | Solanaceae | Solanum lycopersicum | 8.83 | Similar |
| Cucurbitaceae | Cucumis sativus | Solanaceae | Solanum melongena | 9.10 | Highly Similar |
| Cucurbitaceae | Cucumis sativus | Solanaceae | Solanum pennellii | 8.83 | Similar |
| Cucurbitaceae | Cucumis sativus | Solanaceae | Solanum tuberosum | 8.60 | Similar |
| Cucurbitaceae | Cucumis sativus | Poaceae | Sorghum bicolor | 4.91 | Dis similar |
| Cucurbitaceae | Cucumis sativus | Chenopodiaceae | Spinacia oleracea | 9.17 | Highly Similar |