| Family1 | Species1 | Family2 | Species2 | SCUS score | Similarity |
| Cucurbitaceae | Cucurbita maxima | Fabaceae | Glycine soja | 6.69 | Moderately similar |
| Cucurbitaceae | Cucurbita maxima | Malvaceae | Gossypium arboreum | 8.53 | Similar |
| Cucurbitaceae | Cucurbita maxima | Malvaceae | Gossypium hirsutum | 8.53 | Similar |
| Cucurbitaceae | Cucurbita maxima | Malvaceae | Gossypium raimondii | 8.60 | Similar |
| Cucurbitaceae | Cucurbita maxima | Asteraceae | Helianthus annuus | 7.49 | Similar |
| Cucurbitaceae | Cucurbita maxima | Malvaceae | Herrania umbratica | 6.98 | Moderately similar |
| Cucurbitaceae | Cucurbita maxima | Euphorbiaceae | Hevea brasiliensis | 6.14 | Moderately similar |
| Cucurbitaceae | Cucurbita maxima | Poaceae | Hordeum vulgare | 5.45 | Moderately similar |
| Cucurbitaceae | Cucurbita maxima | Euphorbiaceae | Jatropha curcas | 6.89 | Moderately similar |
| Cucurbitaceae | Cucurbita maxima | Asteraceae | Lactuca sativa | 8.66 | Similar |
| Cucurbitaceae | Cucurbita maxima | Fabaceae | Lupinus angustifolius | 6.92 | Moderately similar |
| Cucurbitaceae | Cucurbita maxima | Euphorbiaceae | Manihot esculenta | 6.52 | Moderately similar |
| Cucurbitaceae | Cucurbita maxima | Fabaceae | Medicago truncatula | 7.80 | Similar |
| Cucurbitaceae | Cucurbita maxima | Cucurbitaceae | Momordica charantia | 9.06 | Highly Similar |
| Cucurbitaceae | Cucurbita maxima | Musaceae | Musa acuminata subsp. malaccensis | 7.24 | Similar |
| Cucurbitaceae | Cucurbita maxima | Solanaceae | Nicotiana attenuata | 7.57 | Similar |
| Cucurbitaceae | Cucurbita maxima | Solanaceae | Nicotiana sylvestris | 7.63 | Similar |
| Cucurbitaceae | Cucurbita maxima | Solanaceae | Nicotiana tabacum | 7.60 | Similar |
| Cucurbitaceae | Cucurbita maxima | Solanaceae | Nicotiana tomentosiformis | 7.65 | Similar |
| Cucurbitaceae | Cucurbita maxima | Poaceae | Oryza brachyantha | 5.63 | Moderately similar |